How to Spend Your Oracle Budget: Practical Guidance for Protein Structure Prediction Models
Foundation models for protein structure prediction remain unreliable on certain targets. External oracles can flag and correct these failures, but biological oracles are expensive, making oracle budget a critical constraint. Existing guidance methods, such as FK-steering, DPO, and Best K-of-N sampling, differ in how they spend this budget, yet no systematic comparison exists to guide method selection. To bridge this gap, we benchmark these methods alongside the recently proposed Optimisation Ove
Record details
Published: 12 August 2026
Source: arXiv cs.AI
Category: Research
Topics: Biotech
Retrieved: 13 August 2026
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ethics.ai (12 August 2026), “How to Spend Your Oracle Budget: Practical Guidance for Protein Structure Prediction Models,” evidence record 19032, https://ethics.ai/record/19032 (originally published by arXiv cs.AI).
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