{
  "id": 19032,
  "url": "https://arxiv.org/abs/2608.12192v1",
  "title": "How to Spend Your Oracle Budget: Practical Guidance for Protein Structure Prediction Models",
  "summary": "Foundation models for protein structure prediction remain unreliable on certain targets. External oracles can flag and correct these failures, but biological oracles are expensive, making oracle budget a critical constraint. Existing guidance methods, such as FK-steering, DPO, and Best K-of-N sampling, differ in how they spend this budget, yet no systematic comparison exists to guide method selection. To bridge this gap, we benchmark these methods alongside the recently proposed Optimisation Ove",
  "authors": "Aleksandra Kalisz, Jack Simons, Krisztina Sinkovics, Noam Ghenassia, Shikha Surana, Henry Moss, Paul Duckworth",
  "category": "research",
  "topics": "biotech",
  "orgs": null,
  "regions": null,
  "published_at": "2026-08-12T15:46:57.000Z",
  "fetched_at": "2026-08-13T05:10:37.786Z",
  "source_slug": "x-arxiv-cs-ai",
  "source_name": "arXiv cs.AI",
  "source_homepage": "https://arxiv.org/list/cs.AI/recent",
  "ethics_ai_record_url": "https://ethics.ai/record/19032",
  "original_url": "https://arxiv.org/abs/2608.12192v1",
  "evidence_status": "source-only",
  "attribution": "via ethics.ai"
}