Healthcare

Molecular property prediction constitutes a cornerstone of drug discovery and materials science, necessitating models capable of disentangling complex structure-property relationships across diverse molecular modalities. Existing approaches frequently exhibit entangled representations--conflating structural, chemical, and functional factors--thereby limiting interpretability and transferability. Furthermore, conventional methods inadequately exploit complementary information from graphs, sequenc

Multiphysics simulation frameworks such as MOOSE provide rigorous engines for phase-field materials modeling, yet adoption is constrained by the expertise required to construct valid input files, coordinate parameter sweeps, diagnose failures, and extract quantitative results. We introduce AutoMOOSE, an open-source agentic framework that orchestrates the full simulation lifecycle from a single natural-language prompt. AutoMOOSE deploys a five-agent pipeline in which the Input Writer coordinates

Pathology reports are structured, multi-granular documents encoding diagnostic conclusions, histological grades, and ancillary test results across one or more anatomical sites; yet existing pathology vision-language models (VLMs) reduce this output to a flat label or free-form text. We present HiPath, a lightweight VLM framework built on frozen UNI2 and Qwen3 backbones that treats structured report prediction as its primary training objective. Three trainable modules totalling 15M parameters add

Machine learning systems deployed in medical devices require governance frameworks that ensure safety while enabling continuous improvement. Regulatory bodies including the FDA and European Union have introduced mechanisms such as the Predetermined Change Control Plan (PCCP) and Post-Market Surveillance (PMS) to manage iterative model updates without repeated submissions. This paper presents AI/ML Evaluation and Governance Infrastructure for Safety (AEGIS), a governance framework applicable to a

General-purpose Large Language Models (LLMs) are becoming widely adopted by people for mental health support. Yet emerging evidence suggests there are significant risks associated with high-frequency use, particularly for individuals suffering from psychosis, as LLMs may reinforce delusions and hallucinations. Existing evaluations of LLMs in mental health contexts are limited by a lack of clinical validation and scalability of assessment. To address these issues, this research focuses on psychos

Fine-grained anomaly detection is crucial in industrial and medical applications, but labeled anomalies are often scarce, making zero-shot detection challenging. While vision-language models like CLIP offer promising solutions, they struggle with foreground-background feature entanglement and coarse textual semantics. We propose FB-CLIP, a framework that enhances anomaly localization via multi-strategy textual representations and foreground-background separation. In the textual modality, it comb

Recent vision-language models (VLMs) have shown strong generalization and multimodal reasoning abilities in natural domains. However, their application to medical diagnosis remains limited by the lack of comprehensive and structured datasets that capture real clinical workflows. To advance the development of VLMs for clinical applications, particularly in gastric cancer, we introduce Gastric-X, a large-scale multimodal benchmark for gastric cancer analysis providing 1.7K cases. Each case in Gast

Conventional pixel-wise loss functions fail to enforce topological constraints in coronary vessel segmentation, producing fragmented vascular trees despite high pixel-level accuracy. We present ARIADNE, a two-stage framework coupling preference-aligned perception with RL-based diagnostic reasoning for topologically coherent stenosis detection. The perception module employs DPO to fine-tune the Sa2VA vision-language foundation model using Betti number constraints as preference signals, aligning t

Generative AI (GenAI) is increasingly being integrated into the online ecosystem, including online health communities (OHCs), where people with diverse health conditions exchange social support. For example, in OHCs, support providers are beginning to share content generated, directly or indirectly, by popular GenAI-based tools. OHCs are governed by norms that define appropriate behavior when providing support. Ways in which AI-generated support interacts with these norms remain underexplored. I

This study investigates the adoption and effectiveness of AI-based anomaly detection in cross-provider electronic health record (EHR) environments. It aims to (1) identify the organisational and digital capabilities required for successful implementation and (2) evaluate the performance and interpretability of lightweight anomaly detection approaches using contextual audit data. A semi-systematic scoping synthesis is conducted to derive a four-pillar readiness framework covering governance, infr

This Data Descriptor presents a fully open, multi-modal dataset for estimating vertical ground reaction force (vGRF) from consumer-grade Apple Watch sensors with laboratory force plate ground truth. Ten healthy adults aged 26--41 years performed five activities: walking, jogging, running, heel drops, and step drops, while wearing two Apple Watches positioned at the left wrist and waist. The dataset contains 492 validated trials with time-aligned inertial measurement unit (IMU) recordings (approx

Natural language explanations provide an inherently human-understandable way to explain black-box models, closely reflecting how radiologists convey their diagnoses in textual reports. Most works explicitly supervise the explanation generation process using datasets annotated with explanations. Thus, though plausible, the generated explanations are not faithful to the model's reasoning. In this work, we propose WeNLEX, a weakly supervised model for the generation of natural language explanations

Text-guided image editors can now manipulate authentic medical scans with high fidelity, enabling lesion implantation/removal that threatens clinical trust and safety. Existing defenses are inadequate for healthcare. Medical detectors are largely black-box, while MLLM-based explainers are typically post-hoc, lack medical expertise, and may hallucinate evidence on ambiguous cases. We present MedForge, a data-and-method solution for pre-hoc, evidence-grounded medical forgery detection. We introduc

Medical vision--language models (MVLMs) are increasingly used as perceptual backbones in radiology pipelines and as the visual front end of multimodal assistants, yet their reliability under real clinical workflows remains underexplored. Prior robustness evaluations often assume clean, curated inputs or study isolated corruptions, overlooking routine acquisition, reconstruction, display, and delivery operations that preserve clinical readability while shifting image statistics. To address this g

Large vision-language models (LVLMs) demonstrate strong performance in dermatology; however, evaluating diagnostic reasoning for rare conditions remains largely unexplored. Existing benchmarks focus on common diseases and assess only final accuracy, overlooking the clinical reasoning process, which is critical for complex cases. We address this gap by constructing DermCase, a long-context benchmark derived from peer-reviewed case reports. Our dataset contains 26,030 multi-modal image-text pairs

When VLMs answer correctly, do they genuinely rely on visual information? We introduce a Tri-Layer Diagnostic Framework with three per-sample metrics: Latent Anomaly Detection, Visual Necessity Score, and Competition Score, which disentangle perception, dependency, and alignment failures. Across 9 VLMs and 9,000 model-sample pairs under counterfactual blind, noise, and conflict interventions, 72.9% of samples exhibit Visual Sycophancy, a Split Beliefs pattern in which internal evidence is preser

Background: Clinical trials rely on transparent inclusion criteria to ensure generalizability. In contrast, benchmarks validating health-related large language models (LLMs) rarely characterize the "patient" or "query" populations they contain. Without defined composition, aggregate performance metrics may misrepresent model readiness for clinical use. Methods: We analyzed 18,707 consumer health queries across six public benchmarks using LLMs as automated coding instruments to apply a standardiz

Current alignment evaluation mostly measures whether models encode dangerous concepts and whether they refuse harmful requests. Both miss the layer where alignment often operates: routing from concept detection to behavioral policy. We study political censorship in Chinese-origin language models as a natural experiment, using probes, surgical ablations, and behavioral tests across nine open-weight models from five labs. Three findings follow. First, probe accuracy alone is non-diagnostic: politi

The CARE Workshop on Robotics and AI in Medicine, held on December 1, 2025 in Indianapolis, convened leading researchers, clinicians, industry innovators, and federal stakeholders to shape a national vision for advancing robotics and artificial intelligence in healthcare. The event highlighted the accelerating need for coordinated research efforts that bridge engineering innovation with real clinical priorities, emphasizing safety, reliability, and translational readiness with an emphasis on the

As large language models (LLMs) are deployed in multilingual settings, their safety behavior in culturally diverse, low-resource languages remains poorly understood. We present the first systematic evaluation of LLM safety across 12 Indic languages, spoken by over 1.2 billion people but underrepresented in LLM training data. Using a dataset of 6,000 culturally grounded prompts spanning caste, religion, gender, health, and politics, we assess 10 leading LLMs on translated variants of the prompt.

Automated radiology report generation has gained increasing attention with the rise of deep learning and large language models. However, fully generative approaches often suffer from hallucinations and lack clinical grounding, limiting their reliability in real-world workflows. In this study, we propose a multimodal retrieval-augmented generation (RAG) system for grounded drafting of chest radiograph impressions. The system combines contrastive image-text embeddings, case-based similarity retrie

Cross-Domain Few-Shot Learning (CDFSL) adapts models trained with large-scale general data (source domain) to downstream target domains with only scarce training data, where the research on vision-language models (e.g., CLIP) is still in the early stages. Typical downstream domains, such as medical diagnosis, require fine-grained visual cues for interpretable recognition, but we find that current fine-tuned CLIP models can hardly focus on these cues, albeit they can roughly focus on important re

Reconstructing a 12-lead electrocardiogram (ECG) from a reduced lead set is an ill-posed inverse problem due to anatomical variability. Standard deep learning methods often ignore underlying cardiac pathology losing vital morphology in precordial leads. We propose Pathology-Aware Multi-View Contrastive Learning, a framework that regularizes the latent space through a pathological manifold. Our architecture integrates high-fidelity time-domain waveforms with pathology-aware embeddings learned via

Unified multimodal models share a language model backbone for both understanding and generating images. Can DPO align both capabilities simultaneously? We present the first systematic study of this question, applying DPO to Janus-Pro at 1B and 7B parameters under seven training strategies and two post-hoc methods. The central finding is negative: generation quality resists DPO alignment across all tested conditions on this architecture. No method improves generation CLIPScore at 7B (|Delta| 0.5

3D intraoral scans (IOS) are increasingly adopted in routine dentistry due to abundant geometric evidence, and unified multi-disease diagnosis is desirable for clinical documentation and communication. While recent works introduce dental vision-language models (VLMs) to enable unified diagnosis and report generation on 2D images or multi-view images rendered from IOS, they do not fully leverage native 3D geometry. Such work is necessary and also challenging, due to: (i) heterogeneous scan forms

Generative models are increasingly used to augment medical imaging datasets for fairer AI, yet a key assumption often goes unexamined: that generators produce equally high-quality images across demographic groups. Models trained on imbalanced data inherit these imbalances, degrading synthesis for rare subgroups and struggling with intersections absent from training: the imbalanced generator problem. Remedies such as loss reweighting operate at the optimization level and provide limited benefit w

Predicting drug response in patients from preclinical data remains a major challenge in precision oncology due to the substantial biological gap between in vitro cell lines and patient tumors. Rather than aiming to improve absolute in vitro prediction accuracy, this work examines whether explicitly separating representation learning from task supervision enables more sample-efficient adaptation of drug-response models to patient data under strong biological domain shift. We propose a staged tran

Vision-Language Models (VLMs) offer significant potential in computational pathology by enabling interpretable image analysis, automated reporting, and scalable decision support. However, their widespread clinical adoption remains limited due to the absence of reliable, automated evaluation metrics capable of identifying subtle failures such as hallucinations. To address this gap, we propose PathGLS, a novel reference-free evaluation framework that assesses pathology VLMs across three dimensions

Enterprise IT support is constrained by heterogeneous devices, evolving policies, and long-tail failure modes that are difficult to resolve centrally. We present VIGIL, an edge-extended agentic AI system that deploys desktop-resident agents to perform situated diagnosis, retrieval over enterprise knowledge, and policy-governed remediation directly on user devices with explicit consent and end-to-end observability. In a 10-week pilot of VIGIL's operational loop on 100 resource-constrained endpoin

Human Activity Recognition using wearable inertial sensors is foundational to healthcare monitoring, fitness analytics, and context-aware computing, yet its deployment is hindered by cross-user variability arising from heterogeneous physiological traits, motor habits, and sensor placements. Existing domain generalization approaches either neglect temporal dependencies in sensor streams or depend on impractical target-domain annotations. We propose a different paradigm: modeling generalizable fea

Lung cancer is an extremely fatal kind of cancer, resulting in the deaths of almost 7.6 million individuals annually around the globe. Nevertheless, a timely diagnosis is a crucial necessity for enhancing the likelihood of human survival. Regarding tumor identification, CT scans are normally used to identify affected areas. Nevertheless, CT imaging face significant problems such as poor visibility of tumor locations and high false negative rates. The small dataset size of medical imaging makes i

For novice medical learners, do the benefits of correct AI explanations outweigh the risks of plausible misinformation? In a randomized trial with 111 students, we found they do not. Our results reveal a significant and problematic asymmetry: misleading AI explanations significantly degraded diagnostic accuracy, while correct explanations offered no significant improvement over a no-explanation control. Misleading explanations reduced diagnostic accuracy and showed no evidence of confidence cali

Causal discovery in health data faces evaluation challenges when ground truth is unknown. We address this by collaborating with experts to construct proxy ground-truth graphs, establishing benchmarks for synthetic Alzheimer's disease and heart failure clinical records data. We evaluate the Peter-Clark, Greedy Equivalence Search, and Fast Causal Inference algorithms on structural recovery and path-specific fairness decomposition, going beyond composite fairness scores. On synthetic data, Peter-Cl

Machine learning models deployed in critical care settings exhibit demographic biases, particularly gender disparities, that undermine clinical trust and equitable treatment. This paper introduces FairMed-XGB, a novel framework that systematically detects and mitigates gender-based prediction bias while preserving model performance and transparency. The framework integrates a fairness-aware loss function combining Statistical Parity Difference, Theil Index, and Wasserstein Distance, jointly opti

Increasing staffing constraints and turnaround-time pressures in Prior authorization (PA) have led to increasing automation of decision systems to support PA review. Evaluating fairness in such systems poses unique challenges because legitimate clinical guidelines and medical necessity criteria often differ across demographic groups, making parity in approval rates an inappropriate fairness metric. We propose a fairness evaluation framework for prior authorization models based on model error rat

Large language models appear to develop internal representations of emotion -- "emotion circuits," "emotion neurons," and structured emotional manifolds have been reported across multiple model families. But every study making these claims uses stimuli signalled by explicit emotion keywords, leaving a fundamental question unanswered: do these circuits detect genuine emotional meaning, or do they detect the word "devastated"? We present the first clinical validity test of emotion circuit claims u

Pathological gait analysis is constrained by limited and variable clinical datasets, which restrict the modeling of diverse gait impairments. To address this challenge, we propose a Pathological Gait-conditioned Generative Adversarial Network (PGcGAN) that synthesises pathology-specific gait sequences directly from observed 3D pose keypoint trajectories data. The framework incorporates one-hot encoded pathology labels within both the generator and discriminator, enabling controlled synthesis acr

This work proposes a formal abductive explanation framework designed to systematically uncover rationales underlying AI predictions of mental health help-seeking within tech workplace settings. By computing rigorous justifications for model outputs, this approach enables principled selection of models tailored to distinct psychiatric profiles and underpins ethically robust recourse planning. Beyond moving past ad-hoc interpretability, we explicitly examine the influence of sensitive attributes s

Chain-of-thought (CoT) reasoning has advanced medical visual question answering (VQA), yet most existing CoT rationales are free-form and fail to capture the structured reasoning process clinicians actually follow. This work asks: Can traceable, multi-step reasoning supervision improve reasoning accuracy and the interpretability of Medical VQA? To this end, we introduce Step-CoT, a large-scale medical reasoning dataset with expert-curated, structured multi-step CoT aligned to clinical diagnostic

Large language model (LLM)-based AI agents are increasingly capable of complex clinical reasoning and may soon participate in medical decision-making with limited or no real-time human oversight. This shift raises fundamental questions about how the core principles of medical ethics (i.e., beneficence, nonmaleficence, autonomy, and justice) can be upheld when the clinical responsibility extends to autonomous systems. Here we propose an ethics-by-design framework for medical AI agents comprising