Healthcare

AI systems increasingly shape high-stakes decisions in healthcare, law, defense, and education, yet existing governance paradigms -- AI Ethics, AI Safety, and AI Alignment -- share a common limitation: they evaluate outcomes rather than verifying the reasoning process itself. This paper introduces AI Integrity, a concept defined as a state in which the Authority Stack of an AI system -- its layered hierarchy of values, epistemological standards, source preferences, and data selection criteria --

AI-based image reconstruction models are increasingly deployed in clinical workflows to improve image quality from noisy data, such as low-dose X-rays or accelerated MRI scans. However, these models are typically evaluated using pixel-level metrics like PSNR, leaving their impact on downstream diagnostic performance and fairness unclear. We introduce a scalable evaluation framework that applies reconstruction and diagnostic AI models in tandem, which we apply to two tasks (classification, segmen

Federated learning (FL) performance is highly sensitive to heterogeneity across clients, yet practitioners lack reliable methods to anticipate how a federation will behave before training. We propose readiness indices, derived from Task2Vec embeddings, that quantifies the alignment of a federation prior to training and correlates with its eventual performance. Our approach computes unsupervised metrics -- such as cohesion, dispersion, and density -- directly from client embeddings. We evaluate t

Designing reward functions for reinforcement learning (RL) in healthcare remains challenging because clinically meaningful outcomes are sparse, delayed, and difficult to explicitly specify. Although structured clinical data capture physiologic states, they often fail to reflect broader aspects of patient trajectories such as treatment response, recovery dynamics, and intervention burden. Clinical narratives, by contrast, encode longitudinal clinician assessments of disease progression, treatment

Irregular Medical Time Series play a critical role in the clinical domain to better understand the patient's condition. However, inherent irregularity arising from heterogeneous sampling rates, asynchronous observations, and variable gaps poses key challenges for reliable modeling. Existing methods often distort temporal sampling irregularity and missingness patterns while failing to capture variable decay irregularity, resulting in suboptimal representations. To address these limitations, we in

Institutional decisions -- regulatory compliance, clinical triage, prior authorization appeal -- require a different AI architecture than general-purpose agents provide. Agent frameworks infer authority conversationally, reconstruct accountability from logs, and produce silent errors: incorrect determinations that execute without any human review signal. We propose Cognitive Core: a governed decision substrate built from nine typed cognitive primitives (retrieve, classify, investigate, verify, c

We introduce Agent2 RL-Bench, a compact diagnostic benchmark for evaluating agentic RL post-training, which tests whether LLM agents can autonomously design, implement, debug, and execute post-training pipelines that improve foundation models. RL post-training increasingly drives model alignment and specialization, yet existing benchmarks are largely static, rewarding supervised fine-tuning or script generation without assessing an agent's ability to close an interactive RL loop. Agent2 RL-Bench

Machine learning for tabular data remains constrained by poor schema generalization, a challenge rooted in the lack of semantic understanding of structured variables. This challenge is particularly acute in domains like clinical medicine, where electronic health record (EHR) schemas vary significantly. To solve this problem, we propose Schema-Adaptive Tabular Representation Learning, a novel method that leverages large language models (LLMs) to create transferable tabular embeddings. By transfor

Accurate estimation of cancer risk from longitudinal electronic health records (EHRs) could support earlier detection and improved care, but modeling such complex patient trajectories remains challenging. We present TrajOnco, a training-free, multi-agent large language model (LLM) framework designed for scalable multi-cancer early detection. Using a chain-of-agents architecture with long-term memory, TrajOnco performs temporal reasoning over sequential clinical events to generate patient-level s

Automated insulin delivery (AID) and artificial pancreas systems increasingly serve as safety-critical cyber-physical technologies in clinical care, integrating sensors, algorithms, software, and insulin-delivery hardware to automate a life-sustaining therapy. While regulated commercial systems are supported by formal approval pathways, manufacturer governance, and post-market surveillance, clinicians are also encountering patients who rely on do-it-yourself (DIY) artificial pancreas systems tha

3D medical image analysis is of great importance in disease diagnosis and treatment. Recently, multimodal large language models (MLLMs) have exhibited robust perceptual capacity, strong cross-modal alignment, and promising generalizability. Therefore, they have great potential to improve the performance of medical report generation (MRG) and medical visual question answering (MVQA), which serve as two important tasks in clinical scenarios. However, due to the scarcity of 3D medical images, exist

As Vision-Language Models (VLMs) become integral to educational decision-making, ensuring their fairness is paramount. However, current text-centric evaluations neglect the visual modality, leaving an unregulated channel for latent social biases. To bridge this gap, we present Edu-MMBias, a systematic auditing framework grounded in the tri-component model of attitudes from social psychology. This framework diagnoses bias across three hierarchical dimensions: cognitive, affective, and behavioral.

For patients experiencing cancer, nurse navigation can ease the burden of complex care by enhancing coordination of health services and patient outcomes. However, in under-resourced areas, trained nurse navigators may be limited or non-existent. In the United States, artificial intelligence (AI)-enabled digital health tools are increasingly available and may help address gaps in care coordination; however, most are not designed to specifically support nursing. This perspective piece discusses a

Alzheimer's Dementia (AD) is a progressive neurodegenerative disease marked by irreversible decline, making reliable modeling of its progression essential for effective patient care. Progression-aware methods such as survival analysis are therefore crucial tools for the early detection and monitoring of AD. Recent advancements in deep learning have demonstrated remarkable performance in survival tasks, but alarmingly fewer studies have been conducted in the domain of AD. Further, the studies tha

Medical vision--language models (VLMs) have shown strong potential for medical visual question answering (VQA), yet their reasoning remains largely text-centric: images are encoded once as static context, and subsequent inference is dominated by language. This paradigm is fundamentally limited in clinical scenarios, where accurate answers often depend on subtle, localized visual evidence that cannot be reliably preserved in static embeddings. We propose \textsc{MedLVR}, a latent visual reasoning

Micro-scale street-level economic assessment is fundamental for precision spatial resource allocation. While Street View Imagery (SVI) advances urban sensing, existing approaches remain semantically superficial and overlook brand hierarchy heterogeneity and structural recession. To address this, we propose a visual-semantic and field-based spatiotemporal framework, operationalized via the Street Economic Vitality Index (SEVI). Our approach integrates physical and semantic streetscape parsing thr

To address the unsustainable rise in public health expenditures, the Hong Kong SAR Government is shifting its strategic focus to primary healthcare and encouraging citizens to use community resources to self-manage their health. However, official clinical guidelines are fragmented across disparate departments and formats, creating significant access barriers. While general-purpose Large Language Models (LLMs) such as ChatGPT and DeepSeek offer potential solutions for information accessibility, t

Aligning Large Language Models (LLMs) with high-stakes medical standards remains a significant challenge, primarily due to the dissonance between coarse-grained preference signals and the complex, multi-dimensional nature of clinical protocols. To bridge this gap, we introduce ProMedical, a unified alignment framework grounded in fine-grained clinical criteria. We first construct ProMedical-Preference-50k, a dataset generated via a human-in-the-loop pipeline that augments medical instructions wi

The polygenic risk scores (PRS) have emerged as an important methodology for quantifying genetic predisposition to complex traits and clinical disease. Significant progress has been made in applying PRS to conditions such as obesity, cancer, and type 2 diabetes (T2DM). Studies have demonstrated that PRS can effectively identify individuals at high risk, thereby enabling early screening, personalized treatment, and targeted interventions for diseases with a genetic predisposition. One current lim

A heavily safety-trained model will hand a physician the full, patient-followable benzodiazepine taper and refuse it to the patient who needs it, over identical clinical facts; the knowledge is present either way. IatroBench measures that asymmetry across sixty pre-registered clinical scenarios and six frontier models (3,600 responses), scoring each on two axes, commission harm (what a response gets wrong) and omission harm (what it withholds), through a physician-authored structured evaluation

Understanding the landscape of artificial intelligence (AI) and machine learning (ML) adoption across the National Institutes of Health (NIH) portfolio is critical for research funding strategy, institutional planning, and health policy. The advent of large language models (LLMs) has fundamentally transformed research landscape analysis, enabling researchers to perform large-scale semantic extraction from thousands of unstructured research documents. In this paper, we illustrate a human-in-the-l

Ensuring fairness in machine learning predictions is a critical challenge, especially when models are deployed in sensitive domains such as credit scoring, healthcare, and criminal justice. While many fairness interventions rely on data preprocessing or algorithmic constraints during training, these approaches often require full control over the model architecture and access to protected attribute information, which may not be feasible in real-world systems. In this paper, we propose Counterfact

Current LLM-based services typically require users to submit raw text regardless of its sensitivity. While intuitive, such practice introduces substantial privacy risks, as unauthorized access may expose personal, medical, or legal information. Although prior defenses strived to mitigate these risks, they often incur substantial computational overhead and degrade model performance. To overcome this privacy-efficiency trade-off, we introduce Privacy-Preserving Fine-Tuning (PPFT), a novel training

Maternal and child health is a critical concern around the world. In many global health programs disseminating preventive care and health information, limited healthcare worker resources prevent continuous, personalised engagement with vulnerable beneficiaries. In such scenarios, it becomes crucial to optimally schedule limited live-service resources to maximise long-term engagement. To address this fundamental challenge, the multi-year SAHELI project (2020-2025), in collaboration with partner N

Intersectional biases in healthcare data can produce compound disparities in clinical machine learning models, yet most fairness evaluations assess demographic attributes independently. FairLogue, a toolkit for intersectional fairness auditing, was applied across multiple clinical prediction tasks to evaluate disparities across combined demographic groups. Using the All of Us dataset, two published models were selected for replication and evaluation: (A) prediction of selective serotonin reuptak

Multimodal variational autoencoders (VAEs) have emerged as a powerful framework for survival risk modeling in multiple myeloma by integrating heterogeneous omics and clinical data. However, when trained under survival supervision, standard latent regularization strategies often fail to preserve prognostically relevant variation, leading to unstable or overly constrained representations. Despite numerous proposed variants, it remains unclear which aspects of latent design fundamentally govern per

Hallucinations in medical large language models (LLMs) remain a safety-critical issue, particularly when available evidence is insufficient or conflicting. We study this problem in diabetic retinopathy (DR) decision settings and introduce RETINA-SAFE, an evidence-grounded benchmark aligned with retinal grading records, comprising 12,522 samples. RETINA-SAFE is organized into three evidence-relation tasks: E-Align (evidence-consistent), E-Conflict (evidence-conflicting), and E-Gap (evidence-insuf

Contextual clinical reasoning demands robust inference grounded in complex, heterogeneous clinical records. While state-of-the-art fine-tuning, in-context learning (ICL), and retrieval-augmented generation (RAG) enable knowledge exposure, they often fall short of genuine contextual internalization: dynamically adjusting a model's internal representations to the subtle nuances of individual cases at inference time. To address this, we propose Dual-Stream Calibration (DSC), a test-time training fr

Clinical diagnosis requires sequential evidence acquisition under uncertainty. However, most Large Language Model (LLM) based diagnostic systems assume fully observed patient information and therefore do not explicitly model how clinical evidence should be sequentially acquired over time. Even when diagnosis is formulated as a sequential decision process, it is still challenging to learn effective diagnostic trajectories. This is because the space of possible evidence-acquisition paths is relati

Breast cancer screening relies heavily on mammography, where the craniocaudal (CC) and mediolateral oblique (MLO) views provide complementary information for diagnosis. However, many datasets lack complete paired views, limiting the development of algorithms that depend on cross-view consistency. To address this gap, we propose a three-channel denoising diffusion probabilistic model capable of simultaneously generating CC and MLO views of a single breast. In this configuration, the two mammograp

Community Health Workers (CHWs) play a critical role in delivering primary healthcare services in low-resource settings, yet sustaining their training and performance remains a persistent challenge. Prior research has explored digital and game-based approaches for CHW training. However, limited work has synthesized longitudinal design insights into generalizable guidelines for interactive health interventions. Building on a four-year design-based research program involving multiple game-based re

Deep learning-based modeling of multimodal Electronic Health Records (EHRs) has become an important approach for clinical diagnosis and risk prediction. However, due to diverse clinical workflows and privacy constraints, raw EHRs are inherently multi-level incomplete, including irregular sampling, missing modalities, and sparse labels. These issues cause temporal misalignment, modality imbalance, and limited supervision. Most existing multimodal methods assume relatively complete data, and even

AI agents - i.e. AI systems that autonomously plan, invoke external tools, and execute multi-step action chains with reduced human involvement - are being deployed at scale across enterprise functions ranging from customer service and recruitment to clinical decision support and critical infrastructure management. The EU AI Act (Regulation 2024/1689) regulates these systems through a risk-based framework, but it does not operate in isolation: providers face simultaneous obligations under the GDP

Retrieval-augmented generation (RAG) grounds large language models in external medical knowledge, yet standard retrievers frequently surface hard negatives that are semantically close to the query but describe clinically distinct conditions. While existing query-expansion methods improve query representation to mitigate ambiguity, they typically focus on enriching target-relevant semantics without an explicit mechanism to selectively suppress specific, clinically plausible hard negatives. This l

Recent advances in vision--language pretraining have enabled strong medical foundation models, yet most analyze radiographs in isolation, overlooking the key clinical task of comparing prior and current images to assess interval change. For chest radiographs (CXRs), capturing interval change is essential, as radiologists must evaluate not only the static appearance of findings but also how they evolve over time. We introduce TILA (Temporal Inversion-aware Learning and Alignment), a simple yet ef

Researchers and practitioners are increasingly considering reinforcement learning to optimize decisions in complex domains like robotics and healthcare. To date, these efforts have largely utilized expectation-based learning. However, relying on expectation-focused objectives may be insufficient for making consistent decisions in highly uncertain situations involving multiple heterogeneous groups. While distributional reinforcement learning algorithms have been introduced to model the full distr

Multimodal self-supervised pretraining offers a promising route to cancer prognosis by integrating histopathology whole-slide images, gene expression, and pathology reports, yet most existing approaches require fully paired and complete inputs. In practice, clinical cohorts are fragmented and often miss one or more modalities, limiting both supervised fusion and scalable multimodal pretraining. We propose PRIME, a missing-aware multimodal self-supervised pretraining framework that learns robust

There is substantial interest in developing artificial intelligence systems to support radiologists across tasks ranging from segmentation to report generation. Existing computed tomography (CT) foundation models have largely focused on building generalist vision-language systems capable of tasks such as question answering and report generation. However, training reliable vision-language systems requires paired image-text data at a scale that remains unavailable in CT. Moreover, adapting the und

State-Space Models (SSMs) -- structured SSMs (S4, S4D, DSS, S5), selective SSMs (Mamba, Mamba-2), and hybrid architectures (Jamba) -- are deployed in safety-critical long-context applications: genomic analysis, clinical time-series forecasting, and cybersecurity log processing. Their linear-time scaling is compelling, yet the security properties of their compressed-state recurrent architectures remain unstudied. We present the first systematic treatment of SSM safety, security, and cognitive ris

Rare diseases often manifest with distinctive facial phenotypes in children, offering valuable diagnostic cues for clinicians and AI-assisted screening systems. However, progress in this field is severely limited by the scarcity of curated, ethically sourced facial data and the high similarity among phenotypes across different conditions. To address these challenges, we introduce RDFace, a curated benchmark dataset comprising 456 pediatric facial images spanning 103 rare genetic conditions (aver