Healthcare

High and persistent child malnutrition levels with tardy reduction, seen in successive health surveys, continue to be a matter of concern in India, drawing attention to the need to revamp the four-decade-old Government program, Integrated Child Development Scheme (ICDS). ICDS field functionaries or Anganwadi Workers' (AWWs) capacity deficit was identified as a significant factor affecting ICDS's effectiveness. Considering rising numbers, over 1.4 million AWWs, and continuously advancing knowledg

Microscopy-based phenotypic profiling is scalable for drug discovery but lacks the mechanistic depth of transcriptomics, which remains costly and scarce. Existing multimodal approaches either use images to support other modalities or naively align representations by sample identity, ignoring cell-type and dose variations in weakly paired data-limiting generalization to unseen interventions. In this paper, we introduce an intervention-aware distillation framework that leverages perturbational tra

Extracting clinically relevant information from unstructured medical narratives such as admission notes, discharge summaries, and emergency case histories remains a challenge in clinical natural language processing (NLP). Medical Entity Recognition (MER) identifies meaningful concepts embedded in these records. Recent advancements in large language models (LLMs) have shown competitive MER performance; however, evaluations often focus on general entity types, offering limited utility for real-wor

Automating medical reports for retinal images requires a sophisticated blend of visual pattern recognition and deep clinical knowledge. Current Large Vision-Language Models (LVLMs) often struggle in specialized medical fields where data is scarce, leading to models that overfit and miss subtle but critical pathologies. To address this, we introduce DREAM (Dynamic Retinal Enhancement with Adaptive Multi-modal Fusion), a novel framework for high-fidelity medical report generation that excels even

As Artificial Intelligence (AI) and Agentic AI become increasingly integrated across sectors such as education and healthcare, it is critical to ensure that Multi-Agent Education System (MAES) is explainable from the early stages of requirements engineering (RE) within the AI software development lifecycle. Explainability is essential to build trust, promote transparency, and enable effective human-AI collaboration. Although personas are well-established in human-computer interaction to represen

Subjective NLP datasets typically aggregate annotator judgments into a single gold label, making it difficult to diagnose whether disagreement reflects unclear criteria, collapsed distinctions, or legitimate plurality. We propose a \emph{schema-level diagnostic} for auditing expert-designed annotation schemas \emph{prior to} gold-label commitment, using only multi-annotator criterion judgments. The diagnostic separates two failure modes: unstable criteria with hard-to-operationalize boundaries,

Predicting disease progression from longitudinal imaging is useful for clinical decision making and trial design. Recent methods have moved toward increasing generative complexity, but the conditions under which this complexity is necessary remain unclear. We propose that generative complexity should match the entropy of the predictable component of a task's conditional posterior, with training-inference input alignment required in all regimes. Two model-light measurements, a task-entropy analys

Large language models (LLMs) can generate fluent dialogue, but prior works lack situational grounding, dynamic strategy control, and evaluation aligned with clinical standards in motivational interviewing (MI). We introduce StoryMI, a multi-LLM agent framework for controllable MI dialogue generation, where questionnaire-based client profiles are expanded into situational stories that provide narrative context for the dialogue. Therapist and client agents generate MI-coded utterances guided by MI

We present enclawed, a hard-fork hardening framework built on the OpenClaw AI assistant gateway. enclawed targets deployments that need attestable peer trust, deny-by-default external connectivity, signed-module loading, and a tamper-evident audit trail -- typically regulated industries (financial services, healthcare, defense, government). The framework ships in two flavors: an open flavor preserving OpenClaw compatibility while emitting audit, classification, and data-loss-prevention (DLP) sig

This study seeks to determine the authority signals used by Anthropic's Claude AI in its presentation of sources when answering consumer health questions. While there exists a great deal of discourse around the quality of health citations that LLMs produce, there is limited information on the integrity of the sources the citations originate from, and to what extent the sources are, from what health professionals would consider, credible sources. This descriptive cross-sectional study used data f

Structural health monitoring plays a critical role in ensuring structural safety by analyzing vibration responses from engineering systems. This paper proposes a Spectro-Temporal Alignment framework and a Hybrid Spectro-Temporal Fusion framework that integrate arrival-time interval descriptors with spectral features to capture both fine-scale and coarse-scale vibration dynamics. Experiments conducted on data collected from an LDS V406 electrodynamic shaker demonstrate that the proposed spectro-t

Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a hybrid framework that integrates biomedical knowledge graph structure with large language model-based mechanistic reasoning to enable mechanistically grounded therapeutic prioritization. Across benchmark datasets, DrugKLM outperforms knowledge graph-only and la

Firearm violence is a pressing public health issue, yet research into survivors' lived experiences remains underfunded and difficult to scale. Qualitative research, including in-depth interviews, is a valuable tool for understanding the personal and societal consequences of community firearm violence and designing effective interventions. However, manually analyzing these narratives through thematic analysis and inductive coding is time-consuming and labor-intensive. Recent advancements in large

Spatial reasoning and visual grounding are core capabilities for vision-language models (VLMs), yet most medical VLMs produce predictions without transparent reasoning or spatial evidence. Existing benchmarks also evaluate VLMs on isolated 2D images, overlooking the volumetric nature of clinical imaging, where findings can span multiple frames or appear on only a few slices. We introduce Spatially Grounded MRI Visual Question Answering (SGMRI-VQA), a 41,307-pair benchmark for multi-frame, spatia

Machine learning systems in fraud detection, credit scoring, and clinical risk assessment operate under delayed ground truth: outcome labels arrive days to months after the decision they evaluate. During this blind period, governance evidence degrades through mechanisms that neither drift detection methods nor governance frameworks adequately address. This paper formalizes an evidence sufficiency model with four dimensions (completeness, freshness, reliability, representativeness) and a decision

Large Reasoning Models (LRMs) have demonstrated strong capabilities in generating step-by-step reasoning chains alongside final answers, enabling their deployment in high-stakes domains such as healthcare and education. While prior jailbreak attack studies have focused on the safety of final answers, little attention has been given to the safety of the reasoning process. In this work, we identify a novel problem that injects harmful content into the reasoning steps while preserving unchanged ans

Latent diffusion models have emerged as powerful generative models in medical imaging, enabling the synthesis of high quality brain magnetic resonance imaging scans. In particular, predicting the evolution of a patients brain can aid in early intervention, prognosis, and treatment planning. In this study, we introduce CLIMB, Controllable Longitudinal brain Image generation via state space based latent diffusion model, an advanced framework for modeling temporal changes in brain structure. CLIMB

Machine learning components are now central to AI-infused software systems, from recommendations and code assistants to clinical decision support. As regulations and governance frameworks increasingly require deleting sensitive data from deployed models, machine unlearning is emerging as a practical alternative to full retraining. However, unlearning introduces a software quality-assurance challenge: under realistic deployment constraints and imperfect oracles, how can we test that a model no lo

Trustworthiness and transparency are essential for the clinical adoption of artificial intelligence (AI) in healthcare and biomedical research. Recent deep research systems aim to accelerate evidence-grounded scientific discovery by integrating AI agents with multi-hop information retrieval, reasoning, and synthesis. However, most existing systems lack explicit and inspectable criteria for evidence appraisal, creating a risk of compounding errors and making it difficult for researchers and clini

Simulating group-level user behavior enables scalable counterfactual evaluation of merchant strategies without costly online experiments. However, building a trustworthy simulator faces two structural challenges. First, information incompleteness causes reasoning-based simulators to over-rationalize when unobserved factors such as offline context and implicit habits are missing. Second, mechanism duality requires capturing both interpretable preferences and implicit statistical regularities, whi

The evaluation of fairness in machine learning systems has become a central concern in high-stakes applications, including biometric recognition, healthcare decision-making, and automated risk assessment. Existing approaches typically rely on a small number of fairness metrics to assess model behaviour across group partitions, implicitly assuming that these metrics provide consistent and reliable conclusions. However, different fairness metrics capture distinct statistical properties of model pe

Large language models are increasingly integrated into decision-making in areas such as healthcare, law, finance, engineering, and government. Yet they share a critical limitation: they produce fluent outputs even when their internal reasoning has drifted. A confident answer can conceal uncertainty, speculation, or inconsistency, and small changes in phrasing can lead to different conclusions. This makes LLMs useful assistants but unreliable partners in high-stakes contexts. Humans exhibit a sim

Evaluating large language models (LLMs) for clinical documentation tasks such as SOAP note generation remains challenging. Unlike standard summarization, these tasks require clinical abstraction, normalization of colloquial language, and medically grounded inference. However, prevailing evaluation methods including automated metrics and LLM as judge frameworks rely on lexical faithfulness, often labeling any information not explicitly present in the transcript as hallucination. We show that such

While Large Language Models (LLMs) have demonstrated high proficiency on English-centric medical examinations, their performance often declines when faced with non-English languages and multimodal diagnostic tasks. This study protocol describes the development of EuropeMedQA, the first comprehensive, multilingual, and multimodal medical examination dataset sourced from official regulatory exams in Italy, France, Spain, and Portugal. Following FAIR data principles and SPIRIT-AI guidelines, we des

Large language models (LLMs) are increasingly deployed across healthcare, yet existing benchmarks fail to capture model behavior under adversarial or ethically complex conditions common in clinical practice. We developed a multi-domain red teaming framework evaluating eleven contemporary LLMs across 690 clinically grounded scenarios spanning nine domains and over 150 subcategories. Scenarios incorporated adversarial transformations, and responses were assessed using a seven-dimension rubric with

Reliable and interpretable decision-making is essential in medical imaging, where diagnostic outcomes directly influence patient care. Despite advances in deep learning, most medical AI systems operate as opaque black boxes, providing little insight into why a particular diagnosis was reached. In this paper, we introduce Med-CAM, a framework for generating minimal and sharp maps as evidence-based explanations for Medical decision making via Classifier Activation Matching. Med-CAM trains a segmen

Hybrid Quantum Neural Networks (HQNNs) have recently emerged as a promising paradigm for near-term quantum machine learning. However, their practical performance strongly depends on design choices such as classical-to-quantum data encoding, quantum circuit architecture, measurement strategy and shots. In this paper, we present a comprehensive design space exploration of HQNNs for Chronic Kidney Disease (CKD) diagnosis. Using a carefully curated and preprocessed clinical dataset, we benchmark 625

Vision-language models trained with contrastive learning on paired medical images and reports show strong zero-shot diagnostic capabilities, yet the effect of training batch composition on learned representations remains unexplored for 3D medical imaging. We reproduce Merlin, a dual-encoder model that aligns 3D abdominal CT volumes with radiology reports using symmetric InfoNCE loss, achieving a zero-shot macro F1 of 74.45% across 30 findings (original: 73.00%). We then investigate two axes of v

Temporal credit assignment in reinforcement learning is often approached by introducing value estimates at multiple discount factors. A natural next step is to let the actor dynamically route among these temporal heads, using either differentiable attention or heuristic uncertainty weights. This paper argues that such routing can create a numerical shortcut rather than a reliable temporal abstraction. We study this issue in a controlled PPO setting on LunarLander-v2, using the environment as a v

Conversational generative artificial intelligence agents (or genAI chatbots) could benefit youth mental health, yet young people's perspectives remain underexplored. We examined the Mental health Intelligence Agent (Mia), a genAI chatbot originally designed for professionals in Australian youth services. Following co-design, 32 young people participated in online workshops exploring their perceptions of genAI chatbots in youth mental health and to develop recommendations for reconceptualising Mi

Molecular property optimization is central to drug discovery, yet many deep learning methods rely on black-box scoring and offer limited control over scaffold preservation, often producing unstable or biologically implausible edits. While large language models (LLMs) are promising molecular generators, optimization remains constrained by the lack of chemistry-grounded preference supervision and principled data curation. We introduce \textbf{Scaffold-Conditioned Preference Triplets (SCPT)}, a pip

Letters of recommendation (LoRs) can carry patterns of implicitly gendered language that can inadvertently influence downstream decisions, e.g. in hiring and admissions. In this work, we investigate the extent to which Transformer-based encoder models as well as Large Language Models (LLMs) can infer the gender of applicants in academic LoRs submitted to an U.S. medical-residency program after explicit identifiers like names and pronouns are de-gendered. While using three models (DistilBERT, RoB

Simulating Standardized Patients with cognitive impairment offers a scalable and ethical solution for clinical training. However, existing methods rely on discrete prompt engineering and fail to capture the heterogeneity of deficits across varying domains and severity levels. To address this limitation, we propose StsPatient for the fine-grained simulation of cognitively impaired patients. We innovatively capture domain-specific features by extracting steering vectors from contrastive pairs of i

Latent diffusion models for medical image super-resolution universally inherit variational autoencoders designed for natural photographs. We show that this default choice, not the diffusion architecture, is the dominant constraint on reconstruction quality. In a controlled experiment holding all other pipeline components fixed, replacing the generic Stable Diffusion VAE with MedVAE, a domain-specific autoencoder pretrained on more than 1.6 million medical images, yields +2.91 to +3.29 dB PSNR im

Although artificial intelligence (AI) agents are increasingly proposed to support potentially longitudinal health tasks, such as symptom management, behavior change, and patient support, most current implementations fall short of facilitating user intent and fostering accountability. This contrasts with prior work on supporting longitudinal needs, both within and beyond clinical settings, where follow-up, coherent reasoning, and sustained alignment with individuals' goals are critical for both e

Accurate delineation of the Clinical Target Volume (CTV) is essential for radiotherapy planning, yet remains time-consuming and difficult to assess, especially for complex treatments such as Total Marrow and Lymph Node Irradiation (TMLI). While deep learning-based auto-segmentation can reduce workload, safe clinical deployment requires reliable cues indicating where models may be wrong. In this work, we propose a budget-aware uncertainty-driven quality assurance (QA) framework built on nnU-Net,

Perturbation-based explainability methods such as KernelSHAP provide model-agnostic attributions but are typically impractical for patch-based 3D medical image segmentation due to the large number of coalition evaluations and the high cost of sliding-window inference. We present an efficient KernelSHAP framework for volumetric CT segmentation that restricts computation to a user-defined region of interest and its receptive-field support, and accelerates inference via patch logit caching, reusing

Postmortem avatars (PMAs) -- AI systems that simulate a deceased person by being fine-tuned on data they generated or that was generated about them -- have attracted growing scholarly attention, yet their potential role in clinical settings remains largely unexplored. This paper examines the ethics of deploying PMAs as therapeutic tools in grief therapy. Drawing on the dual-process model of grief, the theory of continuing bonds, and the philosophical framework of fictionalism, we propose two pot

Large language models (LLMs) are increasingly used in clinical and care settings. This exploratory study investigates whether LLMs exhibit sycophantic behavior - adapting their responses to social expectation signals rather than maintaining professional quality - in the context of dementia care. Five prompts with systematically increasing confirmatory and authority-related framing (P1 neutral to P5 authority-signaled implementation support) were submitted to four LLMs (GPT-5, Claude Sonnet 4.6,

India generates vast biomedical data through postgraduate research, government hospital services and audits, government schemes, private hospitals and their electronic medical record (EMR) systems, insurance programs and standalone clinics. Unfortunately, these resources remain fragmented across institutional silos and vendor-locked EMR systems. The fundamental bottleneck is not technological but economic and academic. There is a systemic misalignment of incentives that renders data sharing a hi