Limitations of Sequence-Based Protein Representations for Parkinson's Disease Classification: A Leakage-Free Benchmark
The identification of reliable molecular biomarkers for Parkinson's disease remains challenging due to its multifactorial nature. Although protein sequences constitute a fundamental and widely available source of biological information, their standalone discriminative capacity for complex disease classification remains unclear. In this work, we present a controlled and leakage-free evaluation of multiple representations derived exclusively from protein primary sequences, including amino acid com
Record details
Published: 13 April 2026
Source: arXiv
Category: Research
Topics: Bias & fairness · Biotech
Retrieved: 14 July 2026
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ethics.ai (13 April 2026), “Limitations of Sequence-Based Protein Representations for Parkinson's Disease Classification: A Leakage-Free Benchmark,” evidence record 5971, https://ethics.ai/record/5971 (originally published by arXiv).
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