TriGlue: a Biology-Inspired Generative Model for Generating Molecular Glue-Induced Ternary Complex
Molecular glue degraders have emerged as a promising strategy for targeted protein degradation by inducing ternary complex formation between an E3 ubiquitin ligase and a target protein. Despite their therapeutic potential, computational design of molecular glues remains largely unexplored. Unlike conventional structure-based drug design, molecular glue design is governed by the unknown protein-protein interface and requires the simultaneous modeling of ligand generation, protein-protein docking,
Record details
Published: 3 August 2026
Source: HuggingFace Daily Papers
Category: Research
Topics: Healthcare · Biotech
Retrieved: 6 August 2026
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ethics.ai (3 August 2026), “TriGlue: a Biology-Inspired Generative Model for Generating Molecular Glue-Induced Ternary Complex,” evidence record 16609, https://ethics.ai/record/16609 (originally published by HuggingFace Daily Papers).
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