Healthcare

AI deployment in sensitive domains such as health care, credit, employment, and criminal justice is often treated as unsafe to authorize until model internals can be explained. This often leads to an excessive reliance on mechanistic interpretability to address a deployment challenge beyond its intended scope. We argue that the gate should instead be calibrated verification: authorization should be domain-scoped, independently checkable, monitored after release, accountable, contestable, and rev

Safe fine-tuning defenses are often endorsed on the basis of a held-out gap reduction, but the same reduction can come from sampling noise, subject artifacts, capability loss, or a mechanism that does not transfer. We introduce Acceptance Cards: an evaluation protocol, a documentation object, an executable audit package, and a claim-specific evidential standard for safe fine-tuning defense claims. The protocol checks statistical reliability, fresh semantic generalization, mechanism alignment, an

Medical image segmentation models can perform unevenly across subgroups. Most existing fairness methods focus on improving average subgroup performance, implicitly treating each subgroup as internally homogeneous. However, this can hide difficult cases within a subgroup, where high-loss samples are obscured by the subgroup mean. We call this problem \textbf{intra-group hidden failure}. To solve this, we propose \textbf{DuetFair} mechanism, a dual-axis fairness framework that jointly considers in

Intracranial electrocorticography (ECoG) offers high-signal-to-noise access to cortical activity for brain-computer interfaces, yet limited per-patient data has led most prior work to rely on small, subject-specific decoders that neglect information shared across patients. We investigate whether large pretrained scalp-EEG foundation models (EEG FMs) can be adapted to ECoG, enabling cross-patient learning and competitive decoding performance while calibrating to a held-out patient in 10-30 minute

Designing proteins with desired functions or properties represents a core goal in synthetic biology and drug discovery. Recent advances in protein language models (PLMs) have enabled the generation of highly designable protein sequences, while preference alignment provides a promising way to steer designs toward desired functions and properties. Nevertheless, they often trigger catastrophic forgetting of pretrained knowledge, degrading basic designability and failing to balance multiple competin

Brain-Computer Interfaces (BCIs) based on P300 event-related potentials offer promising applications in health, education, and assistive technologies. However, challenges related to inter- and intra-subject variability and the explainability of Deep Learning (DL) models limit their practical deployment. In this work, we present the Post-Recurrent Module (PRM), an additional layer designed to improve both performance and transparency, incorporated into a Recurrent Neural Network (RNN) architectur

Motor imagery electroencephalography (MI-EEG) decoding offers a non-invasive route for post-stroke rehabilitation, but cross-patient use remains difficult because pathological neural reorganization changes task-related EEG dynamics, aperiodic activity, local excitability, cross-regional coordination, and trial-level brain-state context. This makes source-learned MI representations unreliable for unseen patients. To address this problem, we propose CFSPMNet, a cross-patient adaptation framework t

Accurate spatiotemporal pattern analysis is critical in fields such as urban traffic, meteorology, and public health monitoring. However, existing methods face performance bottlenecks, typically yielding only incremental gains and often exhibiting limited cross-domain transferability. We analyze this bottleneck through spatial and temporal entropy measures, which are used as diagnostic indicators of spatiotemporal complexity mismatch rather than as guarantees that entropy alignment alone yields

Machine learning algorithms are being used in high-stakes decisions, including those in criminal justice, healthcare, credit, and employment. The research community has responded with two largely independent research fields: \emph{algorithmic fairness}, which targets equitable outcomes, and \emph{explainable AI} (XAI), which targets interpretable reasoning. This survey identifies and maps a novel blind spot at their intersection, which is a model that can satisfy every standard fairness criterio

The Metacognitive Probe is an exploratory five-task, 15-slot diagnostic that decomposes an LLM's confidence behaviour into five behaviourally-distinct dimensions: confidence calibration (T1-CC), epistemic vigilance (T2-EV), knowledge boundary (T3-KB), calibration range (T4-CR), and reasoning-chain validation (T5-RCV). It is evaluated on N=8 frontier models and N=69 humans. The instrument is motivated by Flavell (1979) and Nelson and Narens (1990) but operates on observable confidence-correctness

TokaMind is a multi-modal transformer (MMT) foundation model pre-trained on tokamak plasma diagnostics data from MAST, where it was shown to outperform CNN-based approaches on fusion benchmarks. We investigate whether its learned representations generalize to physically distinct but structurally analogous domains. Through systematic experimentation across four domains-industrial bearing degradation, NASA CMAPSS turbofan degradation, and two independent power grid PMU datasets-we identify four tr

Large language models (LLMs) have saturated standard medical benchmarks that test factual recall, yet their ability to perform higher-order reasoning, such as synthesizing evidence from multiple sources, remains critically under-explored. To address this gap, we introduce MedMeta, the first benchmark designed to evaluate an LLM's ability to generate conclusions from medical meta-analyses using only the abstracts of cited studies. MedMeta comprises 81 meta-analyses from PubMed (2018--2025) and ev

AI is transforming life sciences research at unprecedented speed, accelerating discovery across protein structure prediction, genome modeling, and drug development (Jumper et al., 2021; Mak et al., 2024). Yet this rapid advancement, coupled with the open science movement, introduces significant dual-use research concerns that have received limited empirical scrutiny. Here we present the first systematic analysis of dual-use research of concern (DURC) content on open preprint servers. We screened

Voxel-wise dose prediction is a critical yet challenging task in practical radiotherapy (RT) planning, as bespoke models trained from scratch often struggle to generalize across diverse clinical settings. Meanwhile, generative models trained on billion-scale datasets from vision domains have achieved impressive performance. Herein, we propose DiffKT3D, a unified Any2Any 3D diffusion framework that leverages prior knowledge from pretrained video diffusion models for efficient and clinically meani

Inpatient clinical reasoning is a sequential decision under partial observability: the clinician sees the admission so far and must choose the next action whose downstream consequences are not yet visible. Existing clinical-LLM evaluations and RL rewards signals collapse this into closed-form retrieval, clinical journey leakage, or unanchored LLM-as-judge scoring. We introduce CLR-voyance, a framework that reformulates inpatient reasoning as a Partially Observable Markov Decision Process (POMDP)

We introduce SeePhys Pro, a fine-grained modality transfer benchmark that studies whether models preserve the same reasoning capability when critical information is progressively transferred from text to image. Unlike standard vision-essential benchmarks that evaluate a single input form, SeePhys Pro features four semantically aligned variants for each problem with progressively increasing visual elements. Our evaluation shows that current frontier models are far from representation-invariant re

Accurate hand and finger tracking from video has significant clinical applications for monitoring activities of daily living and measuring range of motion, yet monocular video approaches for obtaining hand biomechanics remain under-developed. We present a method that combines the SAM 3D Body foundation model with inverse kinematics optimization in a full-body biomechanical model to extract anatomically-constrained finger joint angles from single-view video. We port SAM 3D Body from PyTorch to JA

Wearable sensors enable the continuous acquisition of high-resolution physiological waveforms, such as photoplethysmography and accelerometry, under free-living conditions. However, inferring health-related phenotypes from these signals presents significant challenges due to high sampling frequencies, multimodal dependencies, and extreme sequence lengths (e.g., weeks of recordings), compounded by a scarcity of ground-truth labels. To address these challenges, existing self-supervised learning (S

We investigate the geometry of predictive information across the layers of large language models (LLMs). We repurpose representation lenses-learned affine maps trained to predict the next token from intermediate residual streams-as geometric diagnostic tools. Rather than asking what the model predicts at each layer, we ask where predictive information resides and how it evolves across depth. We define at each layer a predictive readout subspace as the dominant k-dimensional singular subspace of

The safety of mental health AI is often judged at the wrong temporal scale. Current evaluations typically score isolated responses, endpoint outcomes, or aggregate dialogue quality, while clinically consequential failures may arise from the order and accumulation of interactions themselves, including delayed escalation, repeated reinforcement, dependency formation, failed repair, and gradual deterioration across turns. This paper argues that this mismatch is not merely a limitation of evaluation

Electrocardiography (ECG) is the clinical standard for cardiac assessment but requires dedicated hardware that does not scale to daily-life monitoring. Photoplethysmography (PPG) is ubiquitous in wearables but lacks ECG-specific diagnostic morphology and is corrupted by motion and sensor noise. PPG-to-ECG generation aims to bridge this gap by recovering electrical morphology and timing from peripheral pulse signals. However, existing methods largely rely on statistical alignment and data-driven

The rapid integration of artificial intelligence (AI) into critical infrastructure including healthcare, finance, energy, and defense, offers transformative benefits but also conflicts with evolving regulatory and governance frameworks. This paper presents a systematic literature review (SLR) to examine the challenges of balancing AI compliance and technological innovation across critical infrastructure sectors. The review follows established SLR guidelines to extract and synthesize insights fro

Deep learning models in medical imaging typically operate as parametric memory, diagnosing patients by recalling fixed knowledge learned during training. This contrasts sharply with clinical practice, where physicians employ analogical reasoning to diagnose new cases by referencing similar records from past exemplars. While In-Context Learning (ICL) frameworks such as Tabular Prior-Fitted Networks (TabPFN) offer a promising diagnosis-by-reference paradigm, they are designed with tabular-specific

Discrete diffusion language models (DLMs) generate text by iteratively denoising all positions in parallel, offering an alternative to autoregressive models. Controlled generation methods for DLMs, imported from autoregressive models, apply uniform intervention at every denoising steps. We show this uniform schedule degrades quality, and the damage compounds when multiple attributes are steered jointly. To diagnose the failure, we train sparse autoencoders on four DLMs (124M-8B parameters) and f

Decision Trees (DTs) are widely used in safety-critical domains such as medical diagnosis, valued for their interpretability and effectiveness on tabular data. However, training accurate oblique DTs is challenging due to complex optimization landscapes and overfitting risks, particularly in regression. Recent advances have introduced differentiable formulations that enable gradient-based training and joint optimization of decision boundaries and leaf regressors. Yet, existing approaches typicall

Outcome metrics can certify the wrong behavior. We study this failure in a two-hotel revenue-management simulator where Hotel A trains an agent against a fixed rule-based revenue-management competitor, Hotel B. A standard learning agent can obtain near-reference revenue per available room (RevPAR) while failing to learn market-like yield management: it sells too aggressively, undercuts, or collapses to modal price buckets. We diagnose this as a Goodhart-style failure under partial observability.

Training VideoLLMs for complex reasoning remains challenging due to sparse sequence level rewards and the lack of fine grained credit assignment over long, temporally grounded reasoning trajectories. While reinforcement learning with verifiable rewards (RLVR) provides reliable supervision, it fails to capture token level contributions, leading to inefficient learning. Conversely, existing self distillation methods offer dense supervision but lack structure and diagnostic specificity, and often i

Vision-Language Models (VLMs) increasingly power high-stakes applications, from medical imaging to autonomous systems, yet they routinely hallucinate, confidently describing content not present in the input. We investigate the root causes of these failure modes with a mechanistic analysis focusing on the decoder-based VLMs. We trace these failure modes to a geometric over-alignment: to bridge the modality gap required by attention mechanisms, decoder-based VLMs over-align visual embeddings with

Posterior collapse in variational autoencoders is often diagnosed by its symptoms: a small KL term, a strong decoder, or weak use of the latent code. These signals are useful, but they do not define a collapse boundary. We study a concrete failure mode, input-independent constant collapse, and show that this case admits an exact threshold. For any fixed nonconstant teacher distribution \(T(\cdot\mid x)\), the best constant student is the dataset-average teacher distribution, and its alignment co

Estimating individualized treatment effects from longitudinal observational data is central to data-driven medicine, yet existing methods face a fundamental limitation: reducing confounding bias often suppresses clinically informative heterogeneity, degrading patient-specific predictions. Here, we identify this tension as a bias-precision paradox in causal representation learning and introduce sampling-based maximum mean discrepancy (sMMD), a stochastic alignment strategy that replaces global ad

Automated glaucoma detection is critical for preventing irreversible vision loss and reducing the burden on healthcare systems. However, ensuring fairness across diverse patient populations remains a significant challenge. In this paper, we propose FairEnc, a fair pretraining method for vision-language models (VLMs) that enables simultaneous debiasing across multiple sensitive attributes. FairEnc jointly mitigates biases in both textual and visual modalities with respect to multiple sensitive at

AI chatbots already function as de facto mental health support tools for millions of people, including people in crisis. Yet, they lack the clinical validation, shared standards, and coordinated oversight that their societal role demands. This primer was developed in conjunction with a multistakeholder workshop hosted by Partnership on AI in 2026, convening AI labs, mental health practitioners, people with lived experience, and policymakers, to provide a common cross-sector reference point for t

We present FairHealth, an open-source Python library that provides a unified, modular framework for trustworthy machine learning in healthcare applications, with particular focus on low-resource and low-income country (LMIC) settings such as Bangladesh. FairHealth addresses four critical gaps in existing healthcare AI toolkits: (1) the absence of integrated fairness auditing for biosignals and clinical tabular data; (2) the lack of privacy-preserving federated learning tools compatible with stan

Large Language Models exhibit strong reasoning and semantic understanding capabilities but often hallucinate in domains that require expert knowledge, among which fabrications, the generation of factually incorrect yet fluent statements, pose the greatest risk in medical contexts. Existing medical hallucination datasets inadequately capture fabrication phenomena due to limited fabrication coverage, stylistic disparities between human and LLM-authored texts, and distributional drift during halluc

Protein language models are increasingly used to guide experimental and clinical decisions, yet it is often unclear whether a confident prediction reflects recognition of biological evidence or retrieval of a statistical default. We examine this distinction for a near-universal biological rule, that proteins begin with methionine, by tracing the computational pathway through which ESM2-8M produces this prediction. The model does not detect methionine at the masked position. Instead, it retrieves

Emergency department triage assigns patients an acuity score that determines treatment priority, and clinical evidence documents persistent gender disparities in human acuity assessment. As hospitals pilot large language models (LLMs) as triage decision support, a critical question is whether these models reproduce or mitigate known biases. We present EQUITRIAGE, a fairness audit of LLM-based ESI assignment evaluating five models (Gemini-3-Flash, Nemotron-3-Super, DeepSeek-V3.1, Mistral-Small-3.

Chronic neck pain is a leading cause of disability worldwide, and current treatment selection remains largely trial and error. We present a machine learning framework that uses electroencephalography to predict treatment efficacy in patients with chronic neck pain, with the goal of supporting individualized therapy and reducing the burden on healthcare systems. The framework centers on a rigorous data preprocessing stage tailored to the characteristics of each EEG recording type. For resting-sta

We propose a multimodal latent diffusion model that jointly synthesizes volumetric magnetic resonance imaging (MRI) and tabular clinical data within a shared latent space via cross-attention. This approach enables coherent joint representation learning of MRI and tabular modalities for generative modeling. Our model utilizes a variational autoencoder to fuse the two modalities before diffusion-based synthesis, allowing modality-appropriate reconstruction with separate decoders for MRI and tabula

Vision-Language Models (VLMs) have broad potential in privacy-sensitive domains such as healthcare and finance, yet strict data-sharing constraints render centralized training infeasible. Federated Learning mitigates this issue by enabling decentralized training, but practical deployments face challenges due to client heterogeneity in computational resources, application requirements, and model architectures. Under extreme model and data heterogeneity, replacing parameter aggregation with prefer

Multimodal Large Language Models (MLLMs) have demonstrated robust capabilities in recognizing everyday human activities, yet their potential for analyzing clinically significant involuntary movements in neurological disorders remains largely unexplored. This pilot study evaluates the capability of MLLMs for automated recognition of pathological movements in seizure videos. We assessed the zero-shot performance of state-of-the-art MLLMs on 20 ILAE-defined semiological features across 90 clinical