Healthcare

Recommender systems generally optimises user engagement, but this approach is dangerous in mental health contexts. When vulnerable users show signs of suicidal ideation, standard algorithms often trap them in echo chambers of harmful content, worsening their psychological state. In response, we introduce RankAid, a re-ranking method that prioritises clinical safety alongside predictive relevance. It works as an add-on layer to existing models: it penalises risky items and boosts therapeutic cont

Weakly-supervised classification of whole-slide images with attention-based multiple instance learning (ABMIL) on top of foundation features now reaches near-saturation on Camelyon16 slide-level performance, but the corresponding attention maps are an imperfect localization signal: in clinical interpretation, a model that classifies correctly without firing on the actual lesion is hard to trust. We address this gap with cellular sheaves, which equip each vertex and edge of a graph with a finite-

Radiology reports remain the primary mechanism by which imaging findings are communicated to clinical teams. However, much of the structured information behind these reports, including measurements, image evidence, prior comparisons, lesion identity, uncertainty, and terminology, often remains trapped in free text or fragmented across picture archiving and communication systems, radiology information systems, reporting workstations, worksheets, advanced visualization tools, and electronic health

EEG-based emotion recognition holds significant promise for objective diagnosis of mood disorders. Graph neural networks (GNNs) have emerged as the dominant paradigm for modeling inter-channel dependencies in EEG, yet existing approaches rely on symmetric adjacency matrices derived from spatial proximity or functional correlations that fundamentally capture statistical associations rather than directed causal influences, which conflicts with the inherently asymmetric, causally-driven nature of n

Safety alignment in large language models (LLMs) and multimodal large language models (MLLMs) is commonly assumed to operate as a near-binary threshold mechanism. We challenge this assumption by revealing that safety behavior is governed by an instability region where small perturbations induce stochastic refusal decisions rather than deterministic outcomes. We develop a multi-metric diagnostic framework combining external and internal signals to characterize this instability. Through systematic

Retinal imaging provides a non-invasive window into systemic microvascular health and has emerged as a potential biomarker for systemic diseases. However, whether retinal features encode biologically meaningful systemic signals that can be reliably interpreted using explainable artificial intelligence (XAI) remains unclear. An explainable multi-task deep learning framework was developed to investigate associations between retinal microvascular features and systemic abnormalities in Type 2 Diabet

Visual Autoregressive (VAR) models have emerged as a powerful paradigm for image synthesis by performing hierarchical next-scale prediction. However, VAR models are inherently prone to cascading error propagation, where subtle coarse-scale mispredictions are amplified across the hierarchy, ultimately distorting the final synthesis. To mitigate this, we propose AID-VAR, a plug-and-play framework that enhances pre-trained VARs through Adversarially Injected Diagnosis. Instead of a standard passive

Manufacturing has passed through four widely recognized paradigms - mechanization, electrification, programmable automation, and Smart Manufacturing - each defined by the kind of work it shifted from humans to machines. In every case, one layer of industrial work remained fundamentally human: the coordinative cognition of production, comprising the interpretive, allocative, diagnostic, negotiative, and governance work exercised by engineers, planners, and operational managers. We argue that a fi

The major limitations of gastrointestinal (GI) endoscopy AI systems arise from a shortage of annotated data, strict privacy policies, and significant bottlenecks in conventional model fine-tuning. Such limitations impede the successful application of sophisticated AI models in clinical practice, particularly affecting the reliability and scalability of diagnosis. In this paper, we present a dual-pipeline PEFT model that addresses two fundamental problems: medical Visual Question Answering (VQA)

Minority sampling aims to generate low-density instances on a data manifold and is of central importance in applications such as medical diagnosis, anomaly detection, and creative AI. Existing approaches, however, define minority samples relative to generative priors learned from training data, confining rarity to model-specific notions that may poorly reflect real-world semantics. In this work, we propose a world-centric perspective on minority sampling, which defines rarity with respect to rea

Purpose: Corporate R&D faces a persistent productivity paradox: rising investment and expanding scientific knowledge have not translated into proportional innovation output. In pharmaceuticals this is captured as Eroom's Law; analogous patterns appear across engineering, materials science, and healthcare. The core cause is not insufficient tools but cognitive saturation: researchers spend an increasing share of their effort on coordination, documentation, and data governance -- hidden work that

Healthcare models are transitioning from unimodal prediction toward multimodal reasoning over heterogeneous diagnostic inputs. In computational pathology, for complex tumor subtypes where morphology alone can be challenging to distinguish, pathology reports and molecular measurements may provide additional diagnostic evidence alongside whole-slide images, yet existing models often fail to clarify how diverse signals assemble into recognizable diagnostic concepts. We propose ConceptM$^3$oE (Conce

Secure patient-provider messages contain clinically important communication behaviors that are difficult to characterize manually at scale. The Electronic Patient-Provider Communication (EPPC) framework provides an ontology for coding these behaviors, but automated extraction remains challenging because predictions must preserve fine-grained code/sub-code structure while grounding annotations in message text. We developed EPPC-OASIS, an ontology-aware adaptation approach for structured EPPC extr

Biological systems are governed by structured molecular interactions, where pathways, regulatory circuits, and functional gene relationships shape cellular behavior and disease progression. Much of this knowledge is naturally represented as graphs. However, most biomedical AI models cannot directly use graph-encoded biological knowledge and instead require compressed low-dimensional representations, which can lose important structure and reduce performance, especially in limited-sample clinical

Since 2019, medical societies have reconsidered race-specific clinical equations often in parallel to and largely independent from algorithmic fairness research. Focusing on lung function reference algorithms that affect medical care, insurance, and employment for hundreds of millions globally, we analyze the transition from race-specific GLI-2012 to race-averaged GLI-Global through a fairness lens. Drawing on historical context, citation analysis, and quantitative evaluation, we show (i) limite

General-purpose LLMs are increasingly functioning as mental health infrastructure due to gaps in care left by provider shortages, inadequate insurance coverage, social isolation, and stigma around formal help-seeking. This shift poses a distinct problem for AI ethics: systems neither designed nor governed as care technologies are being used as such, while their dominant design incentives optimize for engagement rather than user well-being. We present findings from a qualitative, longitudinal stu

Large Language Models (LLMs) are optimized to produce distributionally plausible continuations rather than to explicitly verify whether generated propositions are entailed by source documents. This inductive bias enables generalization, but it does not encode whether responses are grounded with respect to a reference. These issues limit the use of LLMs in domains where strict factual correctness is crucial, such as clinical decision support. Existing hallucination detection approaches improve fa

Deep learning has brought significant progress to medical image classification, yet most existing methods still rely on isolated visual evidence and cannot effectively leverage similar cases or external knowledge. In clinical practice, diagnosis is typically supported by similar historical cases and their associated symptoms. To explicitly model this evidence-based diagnostic process, we propose a case-aware reasoning framework driven by multimodal knowledge graphs for medical image classificati

Machine learning practice in institutional decision-support contexts -- government, public policy, public health, criminal justice, resource allocation -- rests on a set of largely unexamined epistemological commitments inherited from classical statistics and computer science: that models represent stable regularities, that validation can be context-free, that performance metrics are politically neutral, and that feature importance reveals system structure. This paper challenges these commitment

Longitudinal passive sensing enables continuous health prediction, yet models often fail under cross-dataset distribution shifts. Traditional ML overfits cohort-specific artifacts, while Large Language Models (LLMs) struggle to reason reliably over long, heterogeneous time-series. We introduce TimeSRL, a two-stage LLM framework that routes predictions through an explicit semantic bottleneck. The model first abstracts raw signals into high-level natural language, then predicts behavioral outcomes

Interpretability in object detection provides crucial confidence support for clinical auxiliary diagnosis. However, in tiny bacteria detection, traditional explanation methods often suffer from blurred foreground boundaries and diffuse feature attribution due to the extreme sparsity of target morphological features and severe interference from complex backgrounds. Such limitations hinder the provision of logically coherent morphological evidence. To bridge this gap, we propose a novel eXplainabl

Automatic speech recognition replaces typing only when correction costs less than manual entry - a threshold determined by error types, not counts: fixing a misrecognized domain term costs far more than inserting a comma. Word error rate (WER) fails on two fronts: it collapses distinct error categories into a single scalar, and it structurally penalizes agglutinative languages where valid sandhi merges inflate scores. We introduce SCRIBE, a diagnostic framework offering categorical error decompo

Medical large language models (LLMs), including custom medical GPTs (MedGPTs) and open-source models, are increasingly deployed on web platforms to provide clinical guidance. However, they pose risks of hallucination, policy noncompliance, and unsafe design. We conduct a large-scale assessment of 6,233 MedGPTs, evaluating a stratified sample of 1,500, together with 10 open-source LLMs. We introduce two frameworks: MedGPT-HEval for hallucination detection and an LLM-based pipeline for assessing p

Artificial intelligence is increasingly moving from single-purpose agricultural recognition tools toward integrated decision-support systems that connect information access, diagnosis, task execution and post-action feedback. This paper presents a design-science case study of the Zhinong AI Agricultural Decision Platform, a farmer-facing system that integrates agricultural information push services, natural-language question answering, image-based crop disease diagnosis, plot and farming-calenda

The growing adoption of AI in healthcare, particularly in preventive care, highlights the critical need for accessibility and precision in Medical Question Answering (MedQA). In recent years, significant efforts have been made to develop multi-span medical question-answering systems, where the answer to a query may span multiple sections or paragraphs of a source document. However, existing systems fall short of aligning with real-world scenarios, where source documents often include both textua

Automated sleep staging is commonly approached as a supervised machine learning problem, with deep learning methods dominating recent research. While machine learning models achieve near-human level agreement with human-scored reference sleep stages, their decisions are typically opaque and not designed to follow clinical scoring rules. We propose a transparent alternative: a deterministic, rule-based sleep staging method that explicitly operationalizes the American Academy of Sleep Medicine's (

Foundation models are increasingly deployed in socially sensitive domains such as education, mental health, and caregiving, where failures are often cumulative and context-dependent. Existing guardrail approaches -- ranging from training-time alignment to prompting, decoding constraints, and post-hoc moderation -- primarily provide empirical risk reduction rather than enforceable behavioral guarantees, and largely treat safety as a property of individual outputs rather than interaction trajector

An effective healthcare agent must be able to recall and reason over a patient's longitudinal medical history. However, the absence of datasets with realistic long-term dialogue timelines limits systematic evaluation. Real clinical text is constrained by privacy and ethics, while existing benchmarks focus on isolated interactions, failing to capture cross-session reasoning. We introduce a framework for synthesizing high-quality, long-term medical dialogues with LLMs. Our approach entails a knowl

Self-evolving skill libraries face a silent failure mode we term \emph{library drift}: unbounded skill accumulation without outcome-driven lifecycle management causes retrieval degradation, false-positive injections, and performance stagnation. Recent evaluation confirms the symptom (LLM-authored skills deliver +0.0pp gain while human-curated ones deliver +16.2pp (SkillsBench)), yet the underlying mechanism has not been isolated. We provide (1) a \textbf{reproducible trigger}: ablations that iso

Machine unlearning in Vertical Federated Learning (VFL) has attracted growing interest, yet existing methods certify forgetting solely using output-level metrics. We challenge these works by introducing Mirage, a representation-level auditing framework that comprises four complementary diagnostics: Linear probe recovery (LPR), centered kernel alignment (CKA), feature separability scoring, and layer-wise recovery analysis. Extensive experiments across seven datasets and seven baseline methods fol

Large Language Models have achieved strong performance on reasoning tasks with objective answers by generating step-by-step solutions, but diagnosing where a multi-step reasoning trace might fail remains difficult. Confidence estimation offers a diagnostic signal, yet existing methods are restricted to final answers or require internal model access. In this paper, we introduce Stepwise Confidence Attribution (SCA), a framework for closed-source LLMs that assigns step-level confidence based only

LLM agents increasingly have access to private user data and act on the user's behalf when interacting with third-party systems. The user defines what may and must not be shared, and the agent must robustly follow that intent even when third-party systems behave adversarially. We introduce POLAR-Bench (Policy-aware adversarial Benchmark), in which a trusted model with a privacy policy and a task converses with a third-party model that adversarially probes for both task-relevant and protected att

High-resolution 3D medical image generation remains challenging because fully volumetric models are computationally expensive, while efficient 2D slice generators often fail to preserve anatomical consistency across the third dimension. We propose LiFT, a framework for Lifted inter-slice Feature Trajectories that factorizes 3D volume synthesis into per-slice image generation and inter-slice trajectory learning. Rather than modeling the volumetric distribution end-to-end, LiFT treats a volume as

Medicine is inherently pluralistic. Principles such as autonomy, beneficence, nonmaleficence, and justice routinely conflict, and such ethical dilemmas often sharply divide reasonable physicians. Good clinical practice navigates these tensions in concert with each patient's values rather than imposing a single ethical stance. The ethical values that large language models bring to medical advice, however, have not been systematically examined. We present a framework for auditing value pluralism i

Tabular foundation models (TFMs) achieve strong performance on health datasets, but their inference cost and infrastructure requirements limit practical use. We study whether their predictive behavior can be transferred to lightweight tabular models through knowledge distillation. Since in-context TFMs condition on the training set at inference time, naive distillation can introduce context leakage; we address this with stratified out-of-fold teacher labeling. Across $19$ healthcare datasets, $6

Cross-domain knowledge alignment is essential for integrating heterogeneous medical systems, yet existing approaches typically treat entity alignment as a static matching problem, ignoring query context and cross-system asymmetry. This limitation is particularly critical in integrative medical settings, where correspondence between concepts is inherently context-dependent, non-bijective, and direction-sensitive. In this paper, we propose Query-Conditioned Entity Alignment (QCEA), which reformula

Vision-language models (VLMs) can couple visual perception with open-ended clinical reasoning, making them attractive for computational histopathology. However, fine-tuning billions of parameters on scarce, expert-annotated pathology data is prohibitive, while in-context learning (ICL), which conditions the VLM on demonstrative image-text pairs without parameter updates, suffers from high sensitivity to which examples are selected and how the query is phrased, producing unreliable diagnostics. E

New item growth is critical for maintaining a healthy ecosystem in large-scale e-commerce platforms. However, existing systems tend to prioritize presenting users with already popular items, a phenomenon often referred to as the "Matthew effect". In the context of search retrieval, current cold-start models suffer from the misalignment between training objectives and online business metrics, and they lack effective mechanisms to measure an item's growth potential. In this paper, we propose a Mul

Domain transfer (DT) maps source to target distributions and supports tasks such as unsupervised image-to-image translation, single-cell analysis, and cross-platform medical imaging. However, DT is fundamentally ill-posed: push-forward mappings are generally non-identifiable, as measure-preserving automorphisms (MPAs) preserve marginals while altering cross-domain correspondences, leading to content-misaligned translation. Recent work shows that MPAs can be eliminated by jointly transferring mul

Self-supervised learning (SSL) is increasingly used in medical image analysis to reduce dependence on costly expert annotations by learning transferable representations from unlabeled data. However, SSL performance depends not only on model architecture, but also on whether the pretext task preserves information required by the downstream clinical objective. This review presents a task-oriented synthesis of SSL methods for medical imaging, focusing on how pretext-task design interacts with imagi