Chamaileon: Cross-Context Binder Design with Contextualized Modeling and Mixed Sampling
The rapid evolution of generative models has unlocked new potentials in protein binder design, a pivotal task in structural biology, by facilitating end-to-end generation via joint sequence-structure modeling or hallucination. However, existing approaches are predominantly implemented under a single-target, single-state assumption, limiting their ability to model multi-target or multi-state interactions required for advanced function-oriented protein design. Here, we introduce Chamaileon, which
Record details
Published: 25 July 2026
Source: HuggingFace Daily Papers
Category: Research
Topics: Biotech
Retrieved: 29 July 2026
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ethics.ai (25 July 2026), “Chamaileon: Cross-Context Binder Design with Contextualized Modeling and Mixed Sampling,” evidence record 14093, https://ethics.ai/record/14093 (originally published by HuggingFace Daily Papers).
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