Optimized Dynamic Network Biomarker Deciphers a High‐Resolution Heterogeneity Within Thyroid Cancer Molecular Subtypes
ABSTRACT The progression of differentiated thyroid carcinoma (DTC) poses significant clinical challenges, especially in determining the optimal time for intervention. To capture early signals of disease progression, we employed an optimized dynamic network biomarker (DNB) method—a systems biology approach that detects abrupt molecular changes indicating a critical transition signal. This analysis revealed that Stage II marks a critical transition in the disease trajectory. We further developed a
OpenAlex
457d ago
HealthcareBiotech