{
  "id": 9525,
  "url": "https://doi.org/10.1038/s41587-024-02143-0",
  "title": "A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models",
  "summary": "Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at the clinical level. We identify TRAF2- and NCK-interacting kinase (TNIK) as an anti-fibrotic target using a predictive artificial intelligence (AI) approach. Using AI-driven methodology, we generated INS018_055, a small-molecule TNIK inhibitor, which exhibits desirable drug-like properties and anti-fibrotic ac",
  "authors": "Feng Ren, Alex Aliper, Jian Chen, Heng Zhao, Sujata Rao, Christoph Kuppe",
  "category": "research",
  "topics": "healthcare",
  "orgs": null,
  "regions": null,
  "published_at": "2024-03-08T00:00:00.000Z",
  "fetched_at": "2026-07-14T16:33:57.576Z",
  "source_slug": "openalex",
  "source_name": "OpenAlex",
  "source_homepage": "https://openalex.org",
  "ethics_ai_record_url": "https://ethics.ai/record/9525",
  "original_url": "https://doi.org/10.1038/s41587-024-02143-0",
  "evidence_status": "source-only",
  "attribution": "via ethics.ai"
}